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Plasma phosphorylated tau 217 and phosphorylated tau 181 as ... - PubMed
pubmed.ncbi.nlm.nih.gov/34418401/
Background: Plasma tau phosphorylated at threonine 217 (p-tau217) and plasma tau phosphorylated at threonine 181 (p-tau181) are associated with ...
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC7983919/
The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons ...
What does it mean if a patient is positive for anti-Jo-1 in routine ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC6058461/
Anti-Jo-1 antibody is a marker of a group of autoimmune diseases that affect the muscles, lungs and skin. This article reviews the clinical features ...
Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC7911942/
Tauvid has been approved by the U.S. Food and Drug Administration (FDA) in 2020 for positron emission tomography (PET) imaging of adult patients with ...
High-specificity antibodies and detection methods for quantifying ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC7944500/
INTRODUCTION. The observation of neurofibrillary tangles (NFTs) in neurons is a defining pathological feature of Alzheimer’s disease (AD). These ...
Brain-derived tau: a novel blood-based biomarker for Alzheimer’s ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC9976981/
The control anti-exon-4 antibody was generated against a recombinant protein form of the exon 4 that is common to all tau isoforms. ( B ) The TauJ.5H3 ...
Initial failures of anti-tau antibodies in Alzheimer’s disease are ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC9241406/
Some anti-Aβ monoclonal antibodies may have marginal beneficial effects in early stages of AD possibly due to their ability to mobilize soluble Aβ ...
New blood test method may predict Alzheimer's disease
www.nih.gov/news-events/nih-research-matters/new-blood-test-method-may-predict-alzheimers-disease
A new blood testing technique could help researchers detect Alzheimer’s disease prior to onset or in those showing early signs of dementia. The ...
Tau; One Protein, So Many Diseases - PMC - National Center for ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC9953016/
Tau. Tau protein, a member of the microtubule-associated protein family, is encoded by the microtubule-associated protein tau gene (MAPT) (Gene ID ...
Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 ...
pubmed.ncbi.nlm.nih.gov/22326685/
Finally, the group of anti-PL7/PL12 positive patients more commonly experienced gastrointestinal manifestations related to ASS (p=0.02). Taken ...
Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC8010148/
Although TfR1 has been used extensively as a target for antibody-mediated cancer therapy over the years, interest continues to increase for both ...
Monophosphoryl lipid A-induced activation of plasmacytoid ... - PubMed
pubmed.ncbi.nlm.nih.gov/32902663/
Monophosphoryl lipid A (MPLA) is a toll-like receptor 4 ligand that promotes immune activation in mice and humans, without undesired inflammation ...
The role of anti-citrullinated protein antibodies (ACPA) in the ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC5820977/
The most specific autoimmunity known for rheumatoid arthritis (RA) is reflected by generation of anti-citrullinated protein antibodies (ACPA) ...
Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC9512290/
Anti-VEGF sustained-release drugs mainly use polymer materials to package anti-VEGF drugs or integrate with the drugs to achieve the purpose of ...
Anti-spike S1 IgA, anti-spike trimeric IgG, and anti-spike RBD IgG ...
pubmed.ncbi.nlm.nih.gov/34616222/
Background: Most studies on immune response after coronavirus disease 2019 (COVID-19) vaccination focused on serum IgG antibodies and cell-mediated ...
Traumatic Brain Injury and Risk of Neurodegenerative Disorder
www.ncbi.nlm.nih.gov/pmc/articles/PMC8636548/
A neuroinflammatory response occurs following acute injury, which includes release of pro- and anti-inflammatory cytokines, neurotrophic factor ...
STAT3 Hyper IgE Syndrome - GeneReviews® - NCBI Bookshelf
www.ncbi.nlm.nih.gov/books/NBK25507/
STAT3 hyper IgE syndrome (STAT3-HIES) is a primary immune deficiency syndrome characterized by elevated serum IgE, eczema, and recurrent skin and ...
Hippocampus and its involvement in Alzheimer’s disease: a review
www.ncbi.nlm.nih.gov/pmc/articles/PMC8807768/
NSCs also increase the response to anti-depressant drugs and help in the subsequent recovery (Kino 2015). The adult NSCs in the hippocampus can grow ...
IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for ...
classic.clinicaltrials.gov/ct2/show/NCT04086264
Assess preliminary antileukemia activity of IMGN632 when administered as a monotherapy in MRD+ Fit and MRD+ Unfit AML patient populations, and in ...